The dual-catalyzed boryldifluoroallylation of alkynes: an efficient method for the synthesis of skipped <i>gem</i>-difluorodienes
Kai‐Feng Zhuo, Wenyan Xu, Tian‐Jun Gong, Yao Fu
Abstract
The Cu/Pd-catalyzed boryldifluoroallylation of alkynes was achieved, providing the corresponding skipped gem-difluorodiene scaffolds with high regio- and stereoselectivity in moderate to excellent yields. This new approach has good functional group compatibility for both alkynes and 3,3-difluoro-substituted allylic esters. Moreover, an array of synthetic building blocks, skipped dienes, trienes, and drug mimics can be obtained via further transformations.
Topics & Concepts
Dual (grammatical number)CatalysisChemistryCombinatorial chemistryDual roleOrganic chemistryArtLiteratureFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsOrganoboron and organosilicon chemistry