The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC
Aaron Javitt, Merav D. Shmueli, Matthias P. Kramer, Aleksandra A. Kolodziejczyk, Ivan Cohen, Lihi Radomir, Daoud Sheban, Iris Kamer, Kevin Litchfield, Elizabeta Bab-Dinitz, Oranit Zadok, Vanessa Neiens, Adi Ulman, Hila Wolf-Levy, Avital Eisenberg‐Lerner, Assaf Kacen, Michal Alon, Ana Toste Rêgo, Elvira Stacher‐Priehse, Michael Lindner, Ina Koch, Jair Bar, Charles Swanton, Yardena Samuels, Yishai Levin, da Fonseca, Eran Elinav, Nir Friedman, Silke Meiners, Yifat Merbl
Topics & Concepts
ProteasomeImmunotherapyImmune systemTumor microenvironmentCancer researchBiologyRegulatorImmunityCancer immunotherapyAntigen presentationImmunologyAntigenCancerT cellCell biologyGeneticsBiochemistryGeneUbiquitin and proteasome pathwaysImmunotherapy and Immune Responsesvaccines and immunoinformatics approaches