Efficient synthesis of 1-iodoalkynes <i>via</i> Al<sub>2</sub>O<sub>3</sub> mediated reaction of terminal alkynes and <i>N</i>-iodosuccinimide
Ming Yao, Jingjing Zhang, Sen Yang, Hangxing Xiong, Li Li, E. Liu, Hong Shi
Abstract
was developed to afford 1-iodoalkynes with good to excellent yields (up to 99%). This described approach featured excellent chemoselectivity, good functional group tolerance, and utilization of an inexpensive catalyst.
Topics & Concepts
Terminal (telecommunication)Combinatorial chemistryChemistryReaction conditionsMedicinal chemistryStereochemistryOrganic chemistryComputer scienceCatalysisComputer networkCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsVanadium and Halogenation Chemistry