Generation and application of Cu-bound alkyl nitrenes for the catalyst-controlled synthesis of cyclic β-amino acids
Raj Kumar Tak, Fuyuki Amemiya, Hidetoshi Noda, Masakatsu Shibasaki
Abstract
)-H bonds among other potentially reactive groups, offering a solution to the chemoselectivity problem that has been troublesome with rhodium catalysis. A combined experimental and computational study suggested that the active species in the current cyclic β-amino acid synthesis is a dicopper alkyl nitrene, which follows a cyclisation pathway distinct from the analogous alkyl metallonitrene.
Topics & Concepts
NitreneAlkylCatalysisChemistryCombinatorial chemistryAmino acidOrganic chemistryBiochemistrySynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsChemical Synthesis and Analysis