Cp*Co(<scp>iii</scp>)-catalyzed thiocarbamate-directed C–H aminocarbonylation, amination, and cascade annulation of pyrroles
Shuvendu Saha, Modhu Sudan Maji
Abstract
one-pot intramolecular cyclization at the thiocarbamoyl directing group. Notably, C-N amidation proceeded smoothly with an elusive catalyst TON of 250 for this Cp*Co(III)-catalysis. Broad scope, scalability, and easy removal of DG are other key features of these methods. The mechanisms of these C-H amidation reactions were proposed through control experiments and DFT calculations.
Topics & Concepts
ThiocarbamateChemistryCatalysisAminationIntramolecular forceCombinatorial chemistryAnnulationMedicinal chemistryCycloisomerizationStereochemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSulfur-Based Synthesis Techniques