Amino Acid Tracer PET MRI in Glioma Management: What a Neuroradiologist Needs to Know
Neetu Soni, Manish Ora, Amarnath Jena, P. Rana, Rajiv Mangla, Shehanaz Ellika, J. Almast, S. Puri, Steven P. Meyers
Abstract
PET with amino acid tracers provides additional insight beyond MR imaging into the biology of gliomas that can be used for initial diagnosis, delineation of tumor margins, planning of surgical and radiation therapy, assessment of residual tumor, and evaluation of posttreatment response. Hybrid PET MR imaging allows the simultaneous acquisition of various PET and MR imaging parameters in a single investigation with reduced scanning time and improved anatomic localization. This review aimed to provide neuroradiologists with a concise overview of the various amino acid tracers and a practical understanding of the clinical applications of amino acid PET MR imaging in glioma management. Future perspectives in newer advances, novel radiotracers, radiomics, and cost-effectiveness are also outlined.