MGF360-9L Is a Major Virulence Factor Associated with the African Swine Fever Virus by Antagonizing the JAK/STAT Signaling Pathway
Keshan Zhang, Bo Yang, Chaochao Shen, Ting Zhang, Hao Yu, Dajun Zhang, Huanan Liu, Xijuan Shi, Guoli Li, Jinke Yang, Dan Li, Zixiang Zhu, Hong Tian, Fan Yang, Yi Ru, Wei Cao, Jianhong Guo, Jijun He, Haixue Zheng, Xiangtao Liu
Abstract
African swine fever—an acute, febrile, hemorrhagic, highly contacting, and highly lethal disease caused by African swine fever virus (ASFV)—jeopardizes the global pig industry. Understanding the mechanism ASFV employs to evade host defense during infection is essential for developing targeted drugs and vaccines against ASFV.
Topics & Concepts
African swine fever virusVirulenceVirologyBiologySTAT1STAT proteinSTAT2VirusInterferonRecombinant DNAGeneSTAT3GeneticsAnimal Disease Management and EpidemiologyVector-Borne Animal DiseasesViral Infections and Immunology Research