Hepatocyte-derived exosomes deliver H2AFJ to hepatic stellate cells and promote liver fibrosis via the MAPK/STMN1 axis activation
Bin Liu, Jinchao Wang, Guangchuan Wang, Wanli Jiang, Zhen Li, Yongjun Shi, Junyong Zhang, Qingshan Pei, Guangjun Huang, Lifen Wang, Shengqiang Zhao, Lei Wu, Mingyan Zhang, Wenwen Wang, Xiao Li, Tong Mou, Chunqing Zhang, Qian Ding
Topics & Concepts
Hepatic stellate cellMicrovesiclesHepatocyteCell biologyMAPK/ERK pathwayBiologyFibrosisCancer researchDownregulation and upregulationGene silencingSignal transductionHepatic fibrosismicroRNAIn vitroMedicinePathologyEndocrinologyBiochemistryGeneLiver physiology and pathologyExtracellular vesicles in diseaseLiver Disease Diagnosis and Treatment