7,8-Dihydroxyflavone protects acetaminophen induced liver injury through activating PI3K/Akt/NRF2/GPX4 mediated ferroptosis suppression
Xintong Pei, Rong Mu, Siyi Liu, Xiong Lu, Xianli Wang, Qi Yao, Hongbo Qi, Hui Li
Topics & Concepts
HepatoprotectionLiver injuryAcetaminophenPharmacologyReactive oxygen speciesChemistryOxidative stressMalondialdehydeLipid peroxidationDownregulation and upregulationMediatorMedicineOxidative phosphorylationAntioxidantGPX4Cancer researchIn vitroTranscriptomeLiver regenerationKEAP1InflammationIn vivoFerroptosis and cancer prognosisDrug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology