Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
Shaian Tavakolian, Hossein Goudarzi, Ebrahim Faghihloo
Abstract
The role of several risk factors, such as pollution, consumption of alcohol, age, sex and obesity in cancer progression is undeniable. Human malignancies are mainly characterized by deregulation of cyclin-dependent kinases (CDK) and cyclin inhibitor kinases (CIK) activities. Viruses express some onco-proteins which could interfere with CDK and CIKs function, and induce some signals to replicate their genome into host's cells. By reviewing some studies about the function of CDK and CIKs in cells infected with oncoviruses, such as HPV, HTLV, HERV, EBV, KSHV, HBV and HCV, we reviewed the mechanisms of different onco-proteins which could deregulate the cell cycle proteins.
Topics & Concepts
Cyclin-dependent kinaseKinaseCancer researchCDK inhibitorCyclinMedicineCell biologyCell cycleBiologyVirologyCancerInternal medicineCancer-related Molecular PathwaysRNA modifications and cancerViral-associated cancers and disorders