Intratumoral delivery of CCL25 enhances immunotherapy against triple-negative breast cancer by recruiting CCR9 <sup>+</sup> T cells
Hongmei Chen, Xiuxiu Cong, Chenxi Wu, Xuan Wu, Jialiang Wang, Kuirong Mao, Jie Li, Ge Zhu, Feiqi Liu, Xiandi Meng, Jia Song, Xu Sun, Xin Wang, Shuhan Liu, Zhang Shi, Xianzhu Yang, Yanqiu Song, Yong-Guang Yang, Tianmeng Sun
Abstract
This study offers an effective strategy to enhance immunotherapy by promoting CCR9 + CD8 + T cell tumor infiltration.
Topics & Concepts
CCL25Cancer researchCD8ImmunotherapyCancer immunotherapyChemokineImmunologyChemistryBiologyImmune systemChemokine receptorImmunotherapy and Immune ResponsesPhagocytosis and Immune RegulationCAR-T cell therapy research