Manganese-deposited iron oxide promotes tumor-responsive ferroptosis that synergizes the apoptosis of cisplatin
Junjie Cheng, Yang Zhu, Xin Xing, Jianmin Xiao, Hui Chen, Hongwei Zhang, Dan Wang, Yuanyuan Zhang, Guilong Zhang, Zhengyan Wu, Yangzhong Liu
Abstract
The Pt-FMO nanoplatform is designed to introduce mutual beneficial cascade reactions for promoting ferroptosis and apoptosis in combination with tumor MRI. The Pt-FMO system, which causes ferroptosis combined with apoptosis, can efficiently induce tumor cell death.
Topics & Concepts
ApoptosisProgrammed cell deathIntracellularChemistryManganese oxideCancer researchCisplatinManganeseCell biologyCellCancer cellMechanism (biology)CancerBiologyBiochemistryChemotherapyGeneticsEpistemologyPhilosophyOrganic chemistryFerroptosis and cancer prognosisNanoparticle-Based Drug DeliveryDrug Transport and Resistance Mechanisms