Albumin-stabilized manganese-based nanocomposites with sensitive tumor microenvironment responsivity and their application for efficient SiRNA delivery in brain tumors
Kai Xu, Zhenghuan Zhao, Junfeng Zhang, Wei Xue, Haipeng Tong, Heng Liu, Weiguo Zhang
Abstract
-weighted imaging performance within the tumor region in a glioblastoma (U87MG) orthotopic model, owing to the intrinsic disproportionation reaction of Mn(iii) in the weakly acidic environment. In addition, these NPs could be used for efficient siRNA delivery. They showed superior advantages in this process, including increased tumour uptake, improved tumor accumulation and enhanced therapeutic effects with the modulation of the TME. These novel albumin-stabilized manganese-based NPs combined with efficient drug delivery capacity hold great potential to serve as intelligent theranostic agents for further clinical translation.
Topics & Concepts
NanocompositeMaterials scienceManganeseResponsivityAlbuminCancer researchTumor microenvironmentBrain tumorNanotechnologyMedicineOptoelectronicsPathologyTumor cellsInternal medicineMetallurgyPhotodetectorGraphene and Nanomaterials ApplicationsNanoparticle-Based Drug DeliveryNanoplatforms for cancer theranostics