Bioaccessibility of Organic Compounds Associated with Tire Particles Using a Fish <i>In Vitro</i> Digestive Model: Solubilization Kinetics and Effects of Food Coingestion
Thibault Masset, B. Ferrari, William Dudefoi, Kristin Schirmer, Alan J. Bergmann, Etiënne L.M. Vermeirssen, Dominique Grandjean, Luke Christopher Harris, Florian Breider
Abstract
. Coingestion caused compound-specific changes in solubilization, either increasing or decreasing the compounds' bioaccessibility in simulated gut fluids compared to CMTT alone. Our results emphasize that tire-associated compounds become accessible in a digestive milieu and should be studied further with respect to their bioaccumulation and toxicological effects upon passage of intestinal epithelial cells.
Topics & Concepts
BioaccumulationEnvironmental chemistryChemistrySolubilizationGammarus pulexDigestion (alchemy)Food scienceBiologyChromatographyBiochemistryFisheryCrustaceanAmphipodaMicroplastics and Plastic PollutionToxic Organic Pollutants ImpactRecycling and Waste Management Techniques