Liver and spleen predominantly mediate calciprotein particle clearance in a rat model of chronic kidney disease
Lara W. Zeper, Caro Bos, Pieter A. Leermakers, Gerben M. Franssen, René Raavé, Joost G.J. Hoenderop, Jeroen H. F. de Baaij
Abstract
Calciprotein particles (CPPs) buffer calcium and phosphate in the blood to prevent formation of crystals. In CKD, increased phosphate levels may exceed the buffering capacity of CPPs, resulting in crystalline CPPs that induce calcification. This study demonstrates that labeled CPPs are predominantly cleared from the circulation in the liver by Kupffer cells, macrophages, and hepatocytes. Our results suggest that targeting liver CPP clearance may reduce the burden of crystalline CPP in the development of vascular calcification.
Topics & Concepts
SpleenKidney diseaseCalcificationKidneyChemistryRenal functionNephrectomyBiodistributionIn vivoInternal medicinePathologyEndocrinologyMedicineIn vitroBiologyBiochemistryBiotechnologyParathyroid Disorders and TreatmentsMagnesium in Health and DiseasePancreatitis Pathology and Treatment