Discovery and functional investigation of BMP4 as a new causative gene for human congenital heart disease
Zhi Wang
Abstract
OBJECTIVE: mutation underlying human CHD and explore its functional impact. METHODS: induced by BMP4 were measured by employing a dual-luciferase analysis system. RESULTS: , two genes whose expression is lost in CHD. CONCLUSION: as a new gene predisposing to human CHD, allowing for improved prenatal genetic counseling along with personalized treatment of CHD patients.
Topics & Concepts
DiseaseHuman diseaseGeneMedicineBioinformaticsHeart diseaseComputational biologyBiologyGeneticsPathologyCongenital heart defects researchCongenital Heart Disease StudiesTissue Engineering and Regenerative Medicine