Withaferin A, a steroidal lactone, selectively protects normal lymphocytes against ionizing radiation induced apoptosis and genotoxicity via activation of ERK/Nrf-2/HO-1 axis
Rahul Checker, Hari N. Bhilwade, Shivani R. Nandha, Raghavendra S. Patwardhan, Deepak Sharma, Santosh K. Sandur
Topics & Concepts
Withaferin AGlutathioneApoptosisChemistryDNA damageBone marrowIonizing radiationCancer researchPharmacologyCancer cellGenotoxicityOxidative stressCell biologyBiochemistryCancerBiologyImmunologyMedicineDNAToxicityGeneticsPathologyWithania somniferaEnzymeIrradiationAlternative medicineNuclear physicsOrganic chemistryPhysicsPhytochemicals and Medicinal PlantsEffects of Radiation ExposureGenomics, phytochemicals, and oxidative stress