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Adoptive transfer of personalized neoantigen-reactive TCR-transduced T cells in metastatic colorectal cancer: phase 2 trial interim results

Maria R. Parkhurst, Stephanie L. Goff, Frank J. Lowery, Rachel K. Beyer, Hyunmi Halas, Paul F. Robbins, Todd D. Prickett, Jared J. Gartner, Sivasish Sindiri, Sri Krishna, Nikolaos Zacharakis, Lien T. Ngo, Satyajit Ray, Alakesh Bera, Ryan P. Shepherd, Noam Levin, Sanghyun P. Kim, Amy R. Copeland, Shirley Nah, Shoshana T. Levi, Neilesh B. Parikh, Mei Li M. Kwong, Nicholas D. Klemen, James C. Yang, Steven A. Rosenberg

2024Nature Medicine73 citationsDOI

Topics & Concepts

Colorectal cancerT-cell receptorInterimMedicineAdoptive cell transferCancerCancer researchImmunologyOncologyInternal medicineT cellImmune systemArchaeologyHistoryCAR-T cell therapy researchBiosimilars and Bioanalytical MethodsCancer Immunotherapy and Biomarkers