Molecular Evolution of Porcine Reproductive and Respiratory Syndrome Virus Field Strains from Two Swine Production Systems in the Midwestern United States from 2001 to 2020
Ruwini Rupasinghe, Kyuyoung Lee, Xin Liu, Phillip C. Gauger, Jianqiang Zhang, Beatriz Martínez‐López
Abstract
= 1,801, 93.3%). We identified that the L5 sequences had more positive selection pressure compared to the L1 strains. Our findings will provide valuable insights into the evolutionary mechanisms of PRRSV-2 and these molecular changes may lead to suboptimal effectiveness of Ingelvac PRRS MLV vaccine.
Topics & Concepts
Porcine reproductive and respiratory syndrome virusBiologyVirologyVirusRespiratory systemGeneticsAnatomyAnimal Virus Infections StudiesViral gastroenteritis research and epidemiologyVirus-based gene therapy research