Heparin Accelerates the Protein Aggregation via the Downhill Polymerization Mechanism: Multi-Spectroscopic Studies to Delineate the Implications on Proteinopathies
Ishfaq Ahmad Ahanger, Zahoor Ahmad Parray, Khalida Nasreen, Faizan Ahmad, Md. Imtaiyaz Hassan, Asimul Islam, Anurag Sharma
Abstract
) are also largely negative, which suggest that the interaction is driven by hydrogen bonding.
Topics & Concepts
ChemistryCircular dichroismIsothermal titration calorimetryHeparinBovine serum albuminBiophysicsGibbs free energyProtein aggregationCooperativityPolymerizationBinding constantConformational changePhotochemistryBiochemistryBinding siteOrganic chemistryPolymerBiologyQuantum mechanicsPhysicsProtein Interaction Studies and Fluorescence AnalysisProteins in Food SystemsProtein Structure and Dynamics