Efferocytosis fuels malignant pleural effusion through TIMP1
Lilan Zhao, Anastasios D. Giannou, Yang Xu, Ahmad Mustafa Shiri, Imke Liebold, Babett Steglich, Tanja Bedke, Tao Zhang, Jöran Lücke, Pasquale Scognamiglio, Jan Kempski, Anna Woestemeier, Jing Chen, Theodora Agalioti, Dimitra E. Zazara, Diana Lindner, Melanie Janning, Jan K. Hennigs, Rajesh Jagirdar, Ourania S. Kotsiou, Sotirios G. Zarogiannis, Yasushi Kobayashi, Jacob R. Izbicki, Sourav Ghosh, Carla V. Rothlin, Lidia Bosurgi, Samuel Huber, Nicola Gagliani
Abstract
substantially reduced MPE progression. Our results delineate an inflammatory cascade-from the clearance of apoptotic cells by Mφs, to production of IL-10, to induction of TIMP1 in DCs-that facilitates MPE progression. This inflammatory cascade offers a series of therapeutic targets for MPE.