Interdomain spacing and spatial configuration drive the potency of IgG-[L]-scFv T cell bispecific antibodies
Brian H. Santich, Jeong A Park, Hoa Tran, Hong-Fen Guo, Morgan Huse, Nai‐Kong V. Cheung
Abstract
) spacers. These findings provide guidelines for improving BsAb function and highlight the importance of spatial configuration and dual bivalency as development parameters.
Topics & Concepts
PotencyAntibodyBispecific antibodyChemistryVirologyMolecular biologyImmunologyCell biologyBiologyMonoclonal antibodyBiochemistryIn vitroMonoclonal and Polyclonal Antibodies ResearchT-cell and B-cell ImmunologyCAR-T cell therapy research