Acetylene containing 2-(2-hydrazinyl)thiazole derivatives: design, synthesis, and<i>in vitro</i>and<i>in silico</i>evaluation of antimycobacterial activity against<i>Mycobacterium tuberculosis</i>
Lakshmi Haritha Bharathi Maganti, Deepthi Ramesh, Balaji Gowrivel Vijayakumar, Mohd. Imran K. Khan, Arunkumar Dhayalan, Jayabal Kamalraja, Tharanikkarasu Kannan
Abstract
. Interestingly, the KasA protein interactions with the compounds were similar to the interactions of KasA protein with thiolactomycin and rifampicin. Cytotoxicity study results indicate that the compounds tested are non-toxic to human embryonic kidney cells.
Topics & Concepts
AntimycobacterialThiazoleMycobacterium tuberculosisAcetyleneIn silicoIn vitroChemistryTuberculosisCombinatorial chemistryMicrobiologyStereochemistryOrganic chemistryMedicineBiologyBiochemistryGenePathologySynthesis and biological activityMulticomponent Synthesis of HeterocyclesSynthesis and Biological Evaluation