Association between T follicular helper cells and T peripheral helper cells with B-cell biomarkers and disease activity in primary Sjögren syndrome
Anastasia Dupré, Juliette Pascaud, Élodie Rivière, Audrey Paoletti, Bineta Ly, Michaël Mingueneau, Xavier Mariette, Gaëtane Nocturne
Abstract
T peripheral helper (Tph) cells are a newly described subtype of T lymphocytes. They are elevated in the blood of patients with pSS and correlate with circulating plasmablasts.
Topics & Concepts
MedicineImmunologyPeripheral bloodDiseaseT helper cellT cellInterleukin 21PeripheralB cellFollicular phaseAntibodyPathologyImmune systemInternal medicineSalivary Gland Disorders and FunctionsChemokine receptors and signalingDiabetes and associated disorders