Viscosity increase/gelation of therapeutic IgG monoclonal antibodies induced by Zn2+: One possible root cause of clogging of staked-in-needle prefilled syringes
Masakazu Fukuda, Tadao Yamazaki, Seıjı Ueno, Akiko Koga, Yuji Yamanaka
Topics & Concepts
ElastomerDynamic light scatteringChemistryViscositySmall-angle X-ray scatteringCloggingMetal ions in aqueous solutionChromatographyMetalAnalytical Chemistry (journal)Nuclear chemistryMaterials scienceScatteringComposite materialNanotechnologyNanoparticleOrganic chemistryHistoryArchaeologyOpticsPhysicsProtein purification and stabilityMonoclonal and Polyclonal Antibodies ResearchBiosimilars and Bioanalytical Methods