Discovery of carbamate-based N-salicyloyl tryptamine derivatives as novel pleiotropic agents for the treatment of Alzheimer's disease
Yuying Wang, Honghua Zhang, Dan Liu, Xuelin Li, Lin Long, Ying Peng, Fujian Qi, Yuqing Wang, Weifan Jiang, Zhen Wang
Topics & Concepts
ChemistryCholinesterasePharmacologyIn vivoTacrineCarbamateTryptamineRivastigmineNeuroprotectionIC50PotencyLead compoundButyrylcholinesterasePharmacokineticsBioavailabilityDrugBlood–brain barrierAcetylcholinesteraseIn vitroBiochemistryEnzymeAchéCentral nervous systemMedicineInternal medicineDementiaDiseaseDonepezilBiotechnologyBiologyCholinesterase and Neurodegenerative DiseasesNicotinic Acetylcholine Receptors StudyComputational Drug Discovery Methods