Light-induced molecular rotation triggers on-demand release from liposomes
Laís Ribovski, Qihui Zhou, Jiawen Chen, Ben L. Feringa, Patrick van Rijn, Inge S. Zuhorn
Abstract
Controllable molecular release from delivery vehicles is essential to successfully reduce drug toxicity and improve therapeutic efficacy. Light-powered hydrophobic molecular motors were therefore incorporated in liposomes to use molecular rotation to facilitate on-demand release. The extent of the release was precisely controlled by irradiation times, providing a simple yet sophisticated responsive molecular nanocarrier.
Topics & Concepts
LiposomeRotation (mathematics)On demandChemistryBiophysicsNanotechnologyMaterials scienceComputer scienceBiologyArtificial intelligenceMultimediaNanoparticle-Based Drug DeliverySupramolecular Chemistry and ComplexesDendrimers and Hyperbranched Polymers