Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib sensitive and resistant melanoma via GPX4 inhibition and metabolic reprogramming
Meng‐Ting Chang, Li‐Chu Tsai, Kyoko Nakagawa‐Goto, Kuo‐Hsiung Lee, Lie‐Fen Shyur
Topics & Concepts
VemurafenibMelanomaReprogrammingProgrammed cell deathCancer researchDownregulation and upregulationMutantChemistryDabrafenibBiochemistryCell biologyBiologyApoptosisCellMetastatic melanomaGeneFerroptosis and cancer prognosisCancer, Lipids, and MetabolismUbiquitin and proteasome pathways