Ketogenic diet: new avenues to overcome colorectal cancer
Yuancai Xiang, Meng Wang, Hongming Miao
Abstract
In a recent article published in Nature, Dmitrieva-Posocco et al. 1 showed that ketogenic diets (KD) exert strong abilities to prevent and treat colorectal cancer (CRC) via the ketone body -hydroxybutyrate (BHB)-mediated hydroxyl-carboxylic receptor. 2 (Hcar2)-homeobox only protein homeobox (Hopx) signaling axis in multiple in vivo and in vitro models (Fig. Intervention of this signaling axis through different settings can restrict the growth of CRC, which provides us a new insight for ketogenic diet-based CRC treatment.
Topics & Concepts
Colorectal cancerKetogenic dietCancerMedicineBioinformaticsOncologyComputational biologyBiologyPhysiologyInternal medicinePsychiatryEpilepsyDiet and metabolism studiesDiet, Metabolism, and DiseaseDigestive system and related health