Three novel quinolinone alkaloids from the leaves of <i>Melicope denhamii</i>
Ratih Dewi Saputri, Rurini Retnowati, Unang Supratman, Tjitjik Srie Tjahjandarie, Mulyadi Tanjung
Abstract
Three previously unreported quinolinone alkaloids: melicodenines J-L (1-3) and six known compounds (4-9), were isolated from the leaves of Melicope denhamii (Seem) T.G. Hartley. The structures of three quinolinone alkaloids were identified based on HRESIMS and NMR spectra. Compounds 1-9 were assayed in three cancer cells (MCF-7, HeLa, and P-388). Compounds 1 and 5 showed high cytotoxic activity against HeLa cells with IC50 values of 1.8 and 0.8 µM, respectively.
Topics & Concepts
HeLaChemistryStereochemistryTwo-dimensional nuclear magnetic resonance spectroscopyCytotoxic T cellIC50AlkaloidTraditional medicineIn vitroBiochemistryMedicineBioactive Compounds and Antitumor AgentsNatural product bioactivities and synthesisPlant chemical constituents analysis