Role of macrophage PKM2 in inflammation and tumor progression and its targeted therapy
Yafei Li, Lingao Zhu, Lu Liu, Bo Li
Topics & Concepts
PKM2InflammationMacrophage polarizationMacrophageImmune systemTumor microenvironmentCancer researchTumor progressionGlycolysisAnaerobic glycolysisCytokineBiologySecretionKinaseLipid metabolismPyruvate kinaseProtein kinase ACell biologyLipid signalingImmunologyMacrophage inflammatory proteinImmunotherapymicroRNASignal transductionChemistryProinflammatory cytokineImmune cells in cancerMacrophage Migration Inhibitory FactorPhagocytosis and Immune Regulation