Endogenous Feline Leukemia Virus (FeLV) siRNA Transcription May Interfere with Exogenous FeLV Infection
Elliott S. Chiu, Coby A. McDonald, Sue VandeWoude
Abstract
approach, we provide evidence of miRNA transcription that is produced in tissues that are most important for FeLV infection, replication, and transmission. Our findings point to important biological functions of enFeLV transcription linked to solo-LTRs distributed within the feline genome, with potential impacts on domestic cat exogenous FeLV susceptibility and pathogenesis. This body of work provides additional evidence of RNA interference (RNAi) as a mechanism of viral interference and is a demonstration of ERV exaptation by the host to defend against related XRVs.
Topics & Concepts
BiologyFeline leukemia virusEndogenous retrovirusLong terminal repeatVirologyEndogenyRetrovirusTranscription (linguistics)Viral InterferenceViral replicationVirusRNA interferenceRNAProvirusReverse transcriptaseMurine leukemia virusBovine leukemia virusPeripheral blood mononuclear cellGroup-specific antigenHaematopoiesisTranscription factorCell culturemicroRNALeukemiaPermissiveCellGeneticsMolecular biologyVirulenceHEK 293 cellsLentivirusViral evolutionVirus-based gene therapy researchChromosomal and Genetic VariationsXenotransplantation and immune response