Exploring the Role of Anti-solvent Effects during Washing on Active Pharmaceutical Ingredient Purity
Muhid Shahid, Georgia Sanxaridou, Sara Ottoboni, Leo Lue, C. Price
Abstract
-heptane as a wash solvent for a PCM crystal slurry resulted in the highest amount of precipitation among the solvent pairs evaluated. This can be mitigated by designing a multi-stage washing strategy where wash solutions of differing wash solvent concentrations are used to minimize step changes in solubility when the mother liquor and the wash solvent come into contact.
Topics & Concepts
Active ingredientSolventCrystallizationDissolutionSolubilityPrecipitationImpurityMother liquorChemistryIngredientChromatographyYield (engineering)Chemical engineeringOrganic chemistryMaterials scienceMetallurgyBiologyBioinformaticsEngineeringPhysicsFood scienceMeteorologyCrystallization and Solubility StudiesInnovative Microfluidic and Catalytic Techniques InnovationAnalytical Chemistry and Chromatography