RORα is critical for mTORC1 activity in T cell-mediated colitis
Xinxin Chi, Wei Jin, Xue Bai, Xiaohong Zhao, Jing Shao, Jiaqi Li, Qinli Sun, Bing Su, Xiaohu Wang, Xuexian O. Yang, Chen Dong
Abstract
T cells in promoting IBD, which may be targeted in human patients.
Topics & Concepts
RAR-related orphan receptor gammamTORC1ColitisTranscriptomeInflammatory bowel diseaseInflammationCancer researchCellBiologyImmunologyCell biologyMedicineDiseaseSignal transductionPI3K/AKT/mTOR pathwayGeneImmune systemGeneticsInternal medicineGene expressionFOXP3T-cell and B-cell ImmunologyCytokine Signaling Pathways and InteractionsIL-33, ST2, and ILC Pathways