Influence of the 2H/1H Isotope Composition of the Water Environment on the Probability of Denaturation Bubble Formation in a DNA Molecule
Alexandr Svidlov, Mikhail Drobotenko, А. А. Басов, А. А. Елкина, E. O. Gerasimenko, В. В. Малышко, М. Г. Барышев, С. С. Джимак
Abstract
The role of single protium–deuterium exchanges in formation of open-state bubbles is investigated using mathematical modeling methods. It is shown that the probability for formation of bubbles with a certain length (12 to 27 nucleotides) depends on localization of the deuterium atom in the DNA molecule and may be appreciably different from the general probability for occurrence of open states.
Topics & Concepts
DeuteriumMoleculeBubbleIsotopeDNAChemical physicsNucleotideLiquid bubbleThermodynamicsChemistryPhysicsAtomic physicsMechanicsNuclear physicsQuantum mechanicsBiochemistryGeneChemical Reactions and IsotopesMass Spectrometry Techniques and ApplicationsRadioactive contamination and transfer