Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know
Gowthami M. Arepally, Thomas L. Ortel
Abstract
The development of vaccines to fight COVID-19 has been a remarkable medical achievement. However, this global immunization effort has been complicated by a rare vaccine-related outcome characterized by thrombocytopenia and thrombosis in association with platelet-activating anti-platelet factor 4 antibodies. In this Spotlight, we will discuss the recently described complication of vaccine-induced immune thrombotic thrombocytopenia (VITT) occurring in response to certain COVID-19 vaccines. Although information about this clinical condition is rapidly evolving, we will summarize our current understanding of VITT.
Topics & Concepts
Need to knowMedicineImmunologyImmune systemComputer scienceComputer securityHeparin-Induced Thrombocytopenia and ThrombosisPlatelet Disorders and TreatmentsBlood groups and transfusion