Sinomenine inhibits macrophage M1 polarization by downregulating α7nAChR via a feedback pathway of α7nAChR/ERK/Egr-1
Yingkun Zhi, Jing Li, Lang Yi, Ruili Zhu, Jin-Fang Luo, Qing-ping Shi, Shasha Bai, Yanwu Li, Qun Du, Jiazhong Cai, Liang Liu, Peixun Wang, Hua Zhou, Yan Dong
Topics & Concepts
SinomenineSmall hairpin RNAMAPK/ERK pathwayChemistryPharmacologyTumor necrosis factor alphaInflammationMacrophage polarizationMacrophagePhosphorylationMedicineIn vitroGene knockdownImmunologyBiochemistryApoptosisNicotinic Acetylcholine Receptors StudyVagus Nerve Stimulation ResearchBerberine and alkaloids research