Frequency of discordance in programmed death-ligand 1 (PD-L1) expression between primary tumors and paired distant metastases in advanced cancers: a systematic review and meta-analysis
Chia Ching Lee, Yu Yang Soon, Jeffrey Huey Yew Lum, Char Loo Tan, Jeremy Tey
Abstract
Approximately one-third of advanced cancer cases have discordance in PD-L1 expression between primary tumors and paired distant metastases. A more liberal testing of PD-L1 expression in both primary and metastatic tumors is recommended in order to identify patients who may benefit from immune checkpoint blockade treatment. Further research exploring the mechanisms and its impact are warranted.
Topics & Concepts
MedicineMeta-analysisOncologyInternal medicineCancerPrimary tumorImmunohistochemistryImmune checkpointPathologyMetastasisImmunotherapyCancer Immunotherapy and BiomarkersBrain Metastases and TreatmentLung Cancer Treatments and Mutations