Synthesis of imidazole-fused nitrogen-bridgehead heterocycles catalysed by lipase and their antifungal and antimicrobial bioactivity
Manjit Singh, Manisha Malviya, Vijay B. Yadav, Aishwarya Nikhil, Munesh Kumar Gupta
Abstract
An effective approach for selective C–N bond formation for synthesising imidazo[1,2- a ] pyridine-based heterocycles using porcine pancreatic lipase (PPL) as a biocatalyst has been devised.
Topics & Concepts
ImidazoleAntimicrobialChemistryLipaseAntifungalBiocatalysisPyridinePancreatic lipaseCombinatorial chemistryOrganic chemistryEnzymeCatalysisMicrobiologyBiologyReaction mechanismEnzyme Catalysis and ImmobilizationChemical synthesis and alkaloidsClick Chemistry and Applications