Development of Polymeric Micelles for Combined Delivery of Luteolin and Doxorubicin for Cancer Therapy
Saad Alshamrani, Ashok Kumar, Mohammed S. Aldughaim, Khalid M. Al-Ghamdi, Muhammad Delwar Hussain, Fars K. Alanazi, Mohsin Kazi
Abstract
PMs with LUT and DOX exhibited significant cytotoxic effects against breast and liver cancer cells and could thus be an important new pharmaceutical formulation to treat cancer.
Topics & Concepts
PoloxamerPoloxamer 407DispersityParticle sizeDrug deliveryDoxorubicinChemistryZeta potentialFourier transform infrared spectroscopyPharmacologyMTT assayMaterials scienceChromatographyNuclear chemistryNanotechnologyNanoparticleMedicineOrganic chemistryChemotherapyChemical engineeringBiochemistryIn vitroSurgeryPolymerCopolymerEngineeringPhysical chemistryNanoparticle-Based Drug DeliveryCancer Treatment and PharmacologyPlant-Derived Bioactive Compounds