BippyPhos: A Highly Versatile Ligand for Pd‐Catalyzed C−N, C−O and C−C Couplings
Robert A. Singer
Abstract
Abstract Numerous ligands have been designed for the Buchwald‐Hartwig Amination (BHA). Among the ligands developed is BippyPhos. This ligand was originally designed to enable a coupling of primary amines with aryl halides. Further studies showed that the ligand has fairly broad utility for Pd‐catalyzed C−N, C−O and C−C couplings. This review describes the various Pd‐catalyzed applications involving BippyPhos as a supporting ligand. While BippyPhos may not often be the most optimal ligand for various Pd‐catalyzed couplings, it typically will provide adequate results as a starting point prior to screening for optimization.
Topics & Concepts
ChemistryAminationLigand (biochemistry)CatalysisHalideCombinatorial chemistryArylPalladiumCoupling (piping)StereochemistryOrganic chemistryBiochemistryAlkylReceptorMechanical engineeringEngineeringCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization Methods