Design, synthesis of DNA-interactive 4-thiazolidinone-based indolo-/pyrroloazepinone conjugates as potential cytotoxic and topoisomerase I inhibitors
Manasa Kadagathur, Sandip Patra, Geetanjali Devabattula, Joel George, Regur Phanindranath, Arbaz Sujat Shaikh, Dilep Kumar Sigalapalli, Chandraiah Godugu, Narayana Nagesh, Neelima D. Tangellamudi, Nagula Shankaraiah
Topics & Concepts
ADMECytotoxicityChemistryTopoisomeraseIn silicoConjugateIn vitroCancer cellPharmacologyBiochemistryStereochemistryCancerBiologyGeneticsMathematicsGeneMathematical analysisCancer therapeutics and mechanismsSynthesis and Biological EvaluationSynthesis and bioactivity of alkaloids