N-Heterocyclic-Carbene-Catalyzed C–H Acylation via Radical Relay
Yunquan Man, Shiwen Liu, Bo Xu, Xiaojun Zeng
Abstract
-fluorocarboxamide-directed N-heterocyclic-carbene (NHC)-catalyzed benzylic C-H acylation with aldehydes via the hydrogen atom transfer strategy is disclosed. This transformation involves a sequence of single-electron transfer, 1,5-hydrogen atom transfer, and radical cross-coupling steps. This method offers facile access to various highly functionalized ketones and exhibits good chemical yields and functional group tolerance.
Topics & Concepts
ChemistryCarbeneCatalysisAcylationMedicinal chemistryRelayCombinatorial chemistryOrganic chemistryPhotochemistryPower (physics)Quantum mechanicsPhysicsN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions