Litcius/Paper detail

Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment

Chiara Falcomatà, Stefanie Bärthel, Sebastian A. Widholz, Christian Schneeweis, Juán José Montero, Albulena Toska, Jonas Mir, Thorsten Kaltenbacher, Jeannine Heetmeyer, Jonathan J. Swietlik, Jingyuan Cheng, Bianca Teodorescu, Oliver Reichert, Constantin Schmitt, Kathrin Grabichler, Andrea Coluccio, Fabio Boniolo, Christian Veltkamp, Magdalena Żukowska, Angelica Arenas Vargas, Woo Hyun Paik, Moritz Jesinghaus, Katja Steiger, Roman Maresch, Rupert Öllinger, Tim Ammon, Olga Baranov, María S. Robles, Julia Rechenberger, Bernhard Küster, Felix Meissner, Maximilian Reichert, Michael Floßdorf, Roland Rad, Marc Schmidt‐Supprian, Günter Schneider, Dieter Saur

2022Nature Cancer105 citationsDOIOpen Access PDF

Topics & Concepts

Cancer researchKRASMesenchymal stem cellTumor microenvironmentImmune checkpointPancreatic cancerTrametinibBiologyCancerMedicineKinaseImmune systemImmunologyImmunotherapyMAPK/ERK pathwayInternal medicineCell biologyColorectal cancerTumor cellsPancreatic and Hepatic Oncology ResearchPhagocytosis and Immune RegulationCancer Immunotherapy and Biomarkers