Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment
Chiara Falcomatà, Stefanie Bärthel, Sebastian A. Widholz, Christian Schneeweis, Juán José Montero, Albulena Toska, Jonas Mir, Thorsten Kaltenbacher, Jeannine Heetmeyer, Jonathan J. Swietlik, Jingyuan Cheng, Bianca Teodorescu, Oliver Reichert, Constantin Schmitt, Kathrin Grabichler, Andrea Coluccio, Fabio Boniolo, Christian Veltkamp, Magdalena Żukowska, Angelica Arenas Vargas, Woo Hyun Paik, Moritz Jesinghaus, Katja Steiger, Roman Maresch, Rupert Öllinger, Tim Ammon, Olga Baranov, María S. Robles, Julia Rechenberger, Bernhard Küster, Felix Meissner, Maximilian Reichert, Michael Floßdorf, Roland Rad, Marc Schmidt‐Supprian, Günter Schneider, Dieter Saur
Topics & Concepts
Cancer researchKRASMesenchymal stem cellTumor microenvironmentImmune checkpointPancreatic cancerTrametinibBiologyCancerMedicineKinaseImmune systemImmunologyImmunotherapyMAPK/ERK pathwayInternal medicineCell biologyColorectal cancerTumor cellsPancreatic and Hepatic Oncology ResearchPhagocytosis and Immune RegulationCancer Immunotherapy and Biomarkers