Dynamic Pathway Regulation Using a Quorum-Sensing Circuit to Improve the Production of L-Homoserine in <i>Escherichia coli</i>
Kun Niu, Miao Zhang, Yi-Ming Kong, Yifan Zhao, Le-Tian Tan, Fan Lu, Zhi‐Qiang Liu, Yu‐Guo Zheng
Abstract
for metabolic flux control, thereby providing novel insights into the rational design of amino acid biosynthesis pathways.
Topics & Concepts
Flux (metallurgy)Quorum sensingMetabolic engineeringCarbon fluxSynthetic biologyMetabolic pathwayFermentationBiosynthesisBiochemical engineeringMetabolic flux analysisMetabolic networkStrain (injury)BiochemistryAmino acidYield (engineering)Production (economics)Rational designComputational biologyChemistryBiologyCompetition (biology)Industrial fermentationFlux balance analysisSystems biologyMetabolismAdaptation (eye)Cell biologyRegulatorGeneBiotechnologyMutantBacterial Genetics and BiotechnologyRNA and protein synthesis mechanismsAmino Acid Enzymes and Metabolism