Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4
Bingxiang Wang, Yishi Shen, Lei Zhai, Xiaodan Xia, Hongmei Gu, Maggie Wang, Yongfang Zhao, Xiaole Chang, Adekunle Alabi, Sijie Xing, Shijun Deng, Boyan Liu, Guiqing Wang, Shucun Qin, Dawei Zhang
Abstract
mice displayed similar levels of liver lipids and plasma alanine aminotransferase activity as control mice, indicating that inhibition of Surf4 does not cause notable liver damage. Expression of stearoyl-CoA desaturase-1 was also reduced in the liver of these mice, suggesting a reduction in de novo lipogenesis. In summary, hepatic deficiency of Surf4 reduced VLDL secretion and the development of atherosclerosis but did not cause significant hepatic lipid accumulation or liver damage.
Topics & Concepts
PCSK9LDL receptorSecretionVery low-density lipoproteinEndocrinologyInternal medicineReceptorChemistryCholesterolLipoproteinBiologyMedicineEndoplasmic Reticulum Stress and DiseaseRNA regulation and diseaseSystemic Lupus Erythematosus Research