Atlas of Exosomal microRNAs Secreted From Human iPSC-Derived Cardiac Cell Types
Mark Chandy, June‐Wha Rhee, Mehmet Ozgün Ozen, Damon Williams, Lejla Pepic, Chun Liu, Hao Zhang, Jessica Malisa, Edward Lau, Utkan Demirci, Joseph C. Wu
Abstract
fibroblasts induced pluripotent stem cells microRNA secretome C ardiac-derived exosomes have received intense interest for their roles in paracrine communications and regenerative therapies. However, current understanding of how exosomes mediate cellular signaling is incomplete, in part because the contents of exosomes from different cardiac cell types are poorly defined. To learn what signals cardiac cells release, we examined the microRNA (miR-NA) compositions secreted in exosomes from human induced pluripotent stem cells (iPSCs) and 3 major iPSC-derived cardiac cell types.
Topics & Concepts
MedicineAtlas (anatomy)microRNACell typeMicrovesiclesInduced pluripotent stem cellCell biologyCellCardiac cellComputational biologyBioinformaticsAnatomyInternal medicineGeneticsBiologyGeneEmbryonic stem cellExtracellular vesicles in diseaseCircular RNAs in diseasesCell Adhesion Molecules Research