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New methyl 5-(halomethyl)-1-aryl-1H-1,2,4-triazole-3-carboxylates as selective COX-2 inhibitors and anti-inflammatory agents: Design, synthesis, biological evaluation, and docking study

Sin‐Min Li, Shuo‐En Tsai, Chia‐Yin Chiang, Cheng‐Yen Chung, Tsung-Jui Chuang, Ching‐Chun Tseng, Wen‐Ping Jiang, Guan‐Jhong Huang, Chin‐Yu Lin, Ya–Chen Yang, Mao-Tsu Fuh, Fung Fuh Wong

2020Bioorganic Chemistry52 citationsDOI

Topics & Concepts

ChemistryAnti-inflammatoryCelecoxibDocking (animal)IC50In vivoIn vitroArylCyclooxygenaseStereochemistryTriazoleCarrageenanPharmacologySelectivityCombinatorial chemistryEnzymeBiochemistryOrganic chemistryCatalysisBiotechnologyNursingBiologyAlkylMedicineSynthesis and Biological EvaluationClick Chemistry and ApplicationsSynthesis and biological activity
New methyl 5-(halomethyl)-1-aryl-1H-1,2,4-triazole-3-carboxylates as selective COX-2 inhibitors and anti-inflammatory agents: Design, synthesis, biological evaluation, and docking study | Litcius