Establishment of a simultaneous assay for lemborexant, a novel dual orexin receptor antagonist, and its three metabolites, and its application to a clinical protein binding study
Yuji Mano, Takashi Ueno, Koichiro Hotta
Topics & Concepts
ChemistryChromatographyAnalyteTandem mass spectrometryExtraction (chemistry)Protein precipitationMass spectrometrySelected reaction monitoringSolid phase extractionMatrix (chemical analysis)Ion suppression in liquid chromatography–mass spectrometryLiquid chromatography–mass spectrometrySleep and Wakefulness ResearchSleep and related disordersCircadian rhythm and melatonin