Human AdV-20-42-42, a Promising Novel Adenoviral Vector for Gene Therapy and Vaccine Product Development
Mónika Z. Ballmann, Svjetlana Raus, Ruben Engelhart, Győző L. Kaján, Abdelaziz Beqqali, Patrick W. F. Hadoke, Chantal van der Zalm, Tibor Papp, Lijo John, Selina Khan, Satish Boedhoe, Katarina Danskog, Lars Frängsmyr, Jerome Custers, Wilfried A.M. Bakker, Hilde M. van der Schaar, Niklas Arnberg, Angelique A. C. Lemckert, Menzo Havenga, Andrew H. Baker
Abstract
Adenoviral vectors are under investigation for a broad range of therapeutic indications in diverse fields, such as oncology and gene therapy, as well as for vaccination both for human and veterinary use. A wealth of data shows that preexisting immune responses may limit the use of a vector.
Topics & Concepts
BiologyViral vectorGenetic enhancementVirologyAdenoviridaeVector (molecular biology)VaccinationImmune systemVirusVectors in gene therapyPopulationTransduction (biophysics)ImmunologyGeneMedicineRecombinant DNAGeneticsBiochemistryEnvironmental healthVirus-based gene therapy researchViral Infectious Diseases and Gene Expression in InsectsCAR-T cell therapy research